By utilizing the new epoxy asphalt concrete pavement (SEA) structure model with the soft Bisar and ANSYS, the main gear configuration and multiple load parameters are analyzed. In the analysis, the influence of the stress and strain and the deflection on surface course pavement are not only calculated, but also the inflection threedimensional interpolation picture fitted by Bisar. When the A380 aircraft is acting on the SEA pavement, the results show that the six wheels in front of main landing gear bear load mainly and the stress and strain distribute uniformity with double peak phenomena. But for the four wheels in rear, the stress and strain on the direction of Y are more than X with concentration phenomena. In addition, a large aircraft like A380 aircraft acting on the epoxy asphalt concrete pavement(SEA) has lesser deflection, having better mechanical effect compared with the normal asphalt concrete pavement(SAA).