The basic connotation of multitarget attack in air combat is analyzed, and an attack sequence and direction planning based on virtual navigation path is proposed. Firstly, the impact of the attack sequence and direction is clarified. Secondly, the planning of attack sequence and direction is equivalent to the programming of the virtual navigation path, the planning space is established, and the principle of navigation path programming and the indexes of feasible route are presented. Then, the concrete coding and the solution methods are given based on the particle swarm optimization (PSO) algorithm. Finally, the computer simulation shows that the method proposed above is effective in solving the problem of the attack sequence and direction planning of multitarget attack, and simultaneously the use of this method can ensure a higher survivability for the fighters in the process of implementing multitarget attach tactics.