The aircraft typical mission profile is chosen from its actual flight data. Through the pretreatment of flight data, rain-counting method and linear cumulative theory, effective loads are extracted and converted into standard cycles，then the profile is divided into four parts to analyze the fatigue damage. The statistical result shows that the fatigue lives of the aircraft right and left engine are submitted to Weibull distribution, but solo-engine is greatly different in fatigue damage. In typical mission section, difference in the take-off and the cruise subsection can reach to 3～4 times, and landing subsection even reach to 10 times for the engines in the same side of different aircraft, however the difference of the fatigue damages for the left-side and the right-side engines in the same aircraft is rather small. The statistical results show that engine fatigue damages are submitted to Weibull distribution. Through implementing single aero-engine life surveillance, flight training can be arranged advisably and engine service life can be prolonged effectively.