According to the viewpoint of combination tope, any convex polyhedron can be composed of some simplexes , and both convex polyhedron and simplex are important concepts of programming theory, so it's necessary to find their volumes in some calculations. Aiming at this problem, a method for volume calculation based on matrix analysis is presented in this paper, and some examples are given to show that this method can be used to solve a class of volume problems in Euclidean space.