The mathematical model of fuze-warhead coordinatlon is founded , and then a digital slmulation system of fuze-warhead coordinatlOn of air-defense missiles is introduced. Taking some air-defense missile and its typical target-MNT -21 for example , the slmulating result is glVen. The dynamic kil1ing range of warhead's fragments and the fragment distribution of hitting target are graphically displayed , which can directly show the fuze-warhead coordinatlOn effect and the damage effect on the target.