At present, existing crack initiation methods and crack propagation methods which can be used to predict rubber fatigue life are not enough, a new method for rubber multi-axis fatigue life prediction based on incremental crack propagation and cracking energy density is proposed. First, a mathematical model of cracking energy density under the finite strain assumption is introduced. Second, assuming that the cracking energy density changes with crack propagation, a functional relationship between the energy release rate and the enewal cracking energy density is established. Finally, a multi-axis fatigue life predic tion model of rubber structure based on incremental crack propagation is established. This model can sim ultaneously achieve prediction of fatigue life and explicit expansion of cracks. The effectiveness of the pro posed method is verified by the numerical examples. The results indicate that the fatigue life prediction model based on incremental crack ropagation is good in prediction accuracy in consideration of high-strain conditions, and the prediction accuracy increases by about twice as compared with the classical crack ener gy density life prediction model.