In view of the safety conflict caused by goaround on the intersecting runway related operation mode, an entire conflict domain of intersecting runway is designed to keep the flight separation between approach goaround and departure aircraft. The entire conflict domain of cross runway conflict is defined as front window and rear window. The collision risk assessment models of the front window and the rear window of the direct and noncross converging runways are established in turn, and then the influence of the runway cross angle on the lateral, longitudinal, vertical directions, and the overall risk is studied. The direct cross convergence runway group of Wichita airport and noncross converging runways group of Tianfu airport are selected as an example. The results show that the entire conflict domain of Tianfu and Wichita airport ranges respectively from 11.89 and 10.93 km before the approach runway entrance to 6.44 and 6.85 km after the entrance. Compared with the timebased wake interval constraint in the regulations, the entire conflict domain of the cross runway can finally determine a safe interval between go around and departure aircraft, and can also provide a reference to the separation of the future domestic cross runway configuration under related operation mode.