Aimed at the problems that aerodynamic noise of specific airframe is often neglected in predicting the flight noise level of aircraft during taking off and landing by the data of ground check, this paper analyzes the airport noise and puts forward a method to predict aerodynamic noise of specific airframe by using FfowcsWilliams & Hawkings acoustic model. Taking the A380 aircraft as an example, simulated and analyzed by Ansys Fluent, the streamline of flow field and sound pressure intensity are obtained. The results show that the airframe noise is a broadband noise, the vortex intensity and pressure fluctuation are mainly concentrated in the ventral wing and aircraft’s underside, increasing gradually from root to tip and reaching the maximum value in the tip region, this phenomenon causes the synthetic sound pressure level which is below the plane is much higher than that on the any other directions.