In order to solve the problem of the optimization of highway runway locating, by the way of investigating and consummating the targets of the highway runway locating, the paper has synthetically considered the requirements in four aspects of usability, technicality, economy and environmental protection to establish the system of evaluating targets for the highway runway locating. Each initial target weights are determined respectively based on the entropy method and the improved AHP method in a combination weighting method, by using the method of composing linear weighting all the target weights are ascertained finally. And then the measuring degree based on the Euclid distance for comparing the opposite closing degrees of all schemes is at a distance from perfect point, then the model of optimizing multiple target decision is established for selecting the best highway runway locating spared schemes. In combination with the living example of highway runway locating, the model of optimizing multiple target decision is tested effectively and practically.